You can have the most horsepower but you have to know how to use it.
To get the horsepower:
Increase bore and stroke to 7.0, make it have 12 cylinders, 4000 on fuel flow rate, get any super or turbo, and make it powerful, use methanol-nitromethane, use 3.5 and 3 on valve size, use the largest drag slicks , and largest front skinnies, and use 2 psi on all tires. Do all of this on a top fuel car and don't change anything else except to use the ford 4 speed auto at the bottom. From here use small setups on the chassis.
Start by messing with the weights, and the wings. Put them on the lowest, and start working to increse the weight and downforce. Save often, if you mess up you may not fix it. If you tweek right you can run a 4.8 at 325!